Polymer Therapeutics: Concepts and Applications

Polymer therapeutics encompass polymer–protein conjugates, drug–polymer conjugates, and supramolecular drug-delivery systems. Numerous polymer–protein conjugates with improved stability and pharmacokinetic properties have been developed, for example, by anchoring enzymes or biologically relevant proteins to polyethylene glycol components (PEGylation). Several polymer–protein conjugates have received market approval, for example the PEGylated form of adenosine deaminase. Coupling low-molecular-weight anticancer drugs to high-molecular-weight polymers through a cleavable linker is an effective method for improving the therapeutic index of clinically established agents, and the first candidates have been evaluated in clinical trials, including, N-(2-hydroxypropyl)methacrylamide conjugates of doxorubicin, camptothecin, paclitaxel, and platinum(II) complexes. 

  • Peptide-based polymer therapeutics
  • Polymersomes as polymer therapeutics for drug delivery
  • Polymer therapeutics as nanomedicines
  • Challenges in polymer therapeutics
  • Polymers for drug–protein conjugates

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